Comprehensive Toxicity Analysis of Individual Ends Tender - 86774765

Description
The Contractor shall investigate the toxicity of 125 flavor ingredient chemicals alone and combined with metal using high throughput assays. The FDA will produce a final library of 125 flavor ingredient chemicals based on the predicted propensity of flavor ingredient chemicals to interact with metals. The Contractor shall perform cytotoxicity assays and measurements of cytokine levels in the supernatant to determine appropriate sublethal concentrations of flavor ingredient chemicals and metals to use in subsequent mutagenic and genotoxic assays, which consist of assays in cells lines and in bacteria. The Contractor shall determine based on measurables of the mutagenic and genotoxic experiments a list of 20 flavor ingredient chemicals and 20 flavor-metal combinations and their concentrations to be tested in the reconstructed human lung tissue model to measure the effects on metabolism, membrane integrity, cell viability, inflammation, and DNA damage. The Contractor shall perform all data analyses, provide FDA all of the raw data, and write study reports.
Active Contract Opportunity

Notice ID : FDA-RFP-75F40123R00115

Related Notice

Department/Ind. Agency : HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Sub-tier : FOOD AND DRUG ADMINISTRATION

Office : FDA OFFICE OF ACQ GRANT SVCS

General Information

Contract Opportunity Type: Combined Synopsis/Solicitation (Updated)

All Dates/Times are: (UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA

Updated Published Date: Aug 04, 2023 12:44 pm EDT

Original Published Date: Jul 20, 2023 01:24 pm EDT

Updated Date Offers Due: Aug 11, 2023 03:00 am EDT

Original Date Offers Due: Aug 04, 2023 01:00 pm EDT

Inactive Policy: 15 days after date offers due

Updated Inactive Date: Aug 26, 2023

Original Inactive Date: Aug 19, 2023

Initiative: None
Classification

Original Set Aside:
Product Service Code: AN31 - Health R&D Services; Consumer and occupational health and safety; Basic Research

NAICS Code: 541690 - Other Scientific and Technical Consulting Services
Place of Performance: USA