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521-17-3-7175-0734 Applied StemCell (VA-17-126822) Tender - 14401321

The AL DEPT. OF VETERANS AFFAIRS MEDICAL CENTER has issued a Tender notice for the procurement of a 521-17-3-7175-0734 Applied StemCell (VA-17-126822) : Service 12 Mth Contract for Research Dept, Mouse Study : aberrant regulation of tumor suppressor g in the USA. This Tender notice was published on 28 Jun 2017 and is scheduled to close on 28 Jun 2017, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 14401321, while the tender notice number is VA24717Q0677 and Registering on the platform.

Procurement Summary

Country: USA

Summary: 521-17-3-7175-0734 Applied StemCell (VA-17-126822) : Service 12 Mth Contract for Research Dept, Mouse Study : aberrant regulation of tumor suppressor g

Deadline: 28 Jun 2017

Posting Date: 28 Jun 2017

Other Information

Notice Type: Tender

TOT Ref.No.: 14401321

Document Ref. No.: VA24717Q0677

Competition: ICB

Financier: Self Financed

Purchaser Ownership: -

Tender Value: Refer Document

Purchaser's Detail

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Tender Details

Tender are invited for The aberrant regulation of tumor suppressor genes and oncogenes play a pivotal role in the transition from normal colon epithelium into carcinoma in situ, and eventually into invasive and metastatic cancer. STRAP, a cellular protein, is upregulated in colorectal cancer and is involved in intestinal cancer progression, metastasis, and chemoresistance. This study is designed to understand, at the molecular level, the mechanism by which STRAP contributes to metastasis of colorectal tumors, cancer stem-like cell self-renewal, and chemotherapeutic resistance. The objective of this project is to generate a TARGATT knockin mouse model with a mouse background of C57BL/6J. The transgene containing the STRAP will be inserted into the Rosa 26 locus gene expression. The model will be developed using CAG-LoxP-LoxP-cDNA (~1kb)-T2A-GFP vector targeting the locus Rosa26 gene expression.

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