Supply and Installation of Spectrometers, Mass Tender - 79714153

Procurement Summary

Country: Hong Kong

Summary: Supply and Installation of Spectrometers, Mass for Department of Chemical Pathology in Prince of Wales Hospital

Deadline: 27 Mar 2023

Posting Date: 03 Mar 2023

Other Information

Notice Type: Tender

TOT Ref.No.: 79714153

Document Ref. No.: NTEC/P&MM/T5B/CBV2324-T003 EOI

Competition: ICB

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

Purchaser's Detail

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Tender Details

Expression of Interest are invited for Supply and Installation of Spectrometers, Mass for Department of Chemical Pathology in Prince of Wales Hospital (“Pwh”), New Territories East Cluster (“Ntec”), Hospital Authority (“Ha”)
M/D/O (Please tick as appropriate)

1.1.2 Validated chromatographic methods such as application notes

and published methods for the separation of each of the

following analytes in biological samples. The details of

chromatographic separation shall include but not be limited to the

composition and gradient of the mobile phase solutions, flow

rate, injection volume, total run time and type and temperature of

analytical column.

(a) Plasma amino acids

(b) Plasma renin activity

(c) Plasma/serum aldosterone

(d) Plasma metanephrines

(e) Serum/plasma estrogens

(M)

1.1.3 Validated data acquisition methods such as application notes and

published methods of the tandem mass spectrometer (MS/MS)

for the detection of each of the following analytes in biological

samples. The details of mass spectrometric detection shall

include but not be limited to the adjustable parameters of ion

source and data acquisition. A nitrogen generation

complementary to the proposed SYSTEM shall be provided.

(a) Plasma amino acids

(b) Plasma renin activity

(c) Plasma/serum aldosterone levels

(d) Plasma metanephrines

(e) Serum/plasma estrogens

(M)

1.1.4 A data processing software for analysing the acquired mass

spectrometry (MS) data.

(M)

1.1.5 Connectivity to Laboratory Information System (LIS). This shall

include but not be limited to the hardware and software and their

customization to fulfil the requirements of LIS at Appendix I

and PWH.

(M)

1.1.6 If applicable, Tenderers shall provide a reliable anti-virus,

anti-spyware and anti-hacking solution for the medical

equipment/system on offer. The solution provided shall not affect

the normal performance of the equipment/system. Details of the

solution shall be stated. Tenderers shall regularly update the

anti-virus program. Preferably using hospital's virus definition,

that is, to connect to hospital network for the daily update of

anti-virus program. The successful Tenderer is required to follow

the latest HA network security policies and guidelines.

(M)

9

EOI Ref.: NTEC/P&MM/T5B/CBV2324-T003 EOI

Clause Description Type of

Clause

YES NO

(Provide

details)

M/D/O (Please tick as appropriate)

1.1.7 Provide uninterrupted power supply devices (UPS) to all

components specified in this tender specifications whenever

appropriate. The UPS shall be maintenance-free and sealed type

and equipped with environmental friendly batteries, to maintain

operation for at least 15 minutes during power failure.

(M)

1.2 The Tenderer shall provide brand new equipment and all the

related software.

(M)

1.3 Provide all reagents, quality controls, calibrators and

consumables as well as manpower of qualifying personnel for the

functional and acceptance testing of the equipment in this tender

specifications.

PWH reserves final right to design and decide the scope of

evaluation and its criteria of acceptance in concordance with

international standards, e.g. Clinical Laboratory Standard

Institute (CLSI) and laboratory-s accrediting bodies, e.g.

National Association of Testing Authorities, Australia and/or

Hong Kong Laboratory Accreditation Scheme (HOKLAS).

(M)

1.4 The SYSTEM shall occupy space as designated by PWH. The

Tenderer are required to perform a pre-tender site visit to study

and confirm space and associated facilities for the proposed

SYSTEM and shall confirm in writing that the conditions of the

installation site are suitable for equipment installation in their

tender submission. The proposed SYSTEM required more

physical space shall NOT be considered.

(M)

10

EOI Ref.: NTEC/P&MM/T5B/CBV2324-T003 EOI

Clause Description Type of

Clause

YES NO

(Provide

details)

M/D/O (Please tick as appropriate)

1.5 Site Renovation/ Modification

The Tenderer shall carefully study and confirm the existing

facilities and infrastructure in the designated area of PWH

including but not limited to gas exhaust, electricity supply, water

supply and concealed or under floor ducting being adequate and

suitable for the proposed SYSTEM. If site renovation/

modification is required for the accommodation, installation

and implementation of the proposed SYSTEM, the Tenderer

shall provide design, plan and details in the tender

submission. The Tenderer-s site modification work

requirements should be clearly depicted in appropriate drawings,

which should be accompanied by detailed information with

cross-reference, where applicable, to the drawings. The site

renovation/ modification work details shall include but not be

limited to the dimensions, layout, openings and other relevant

information regarding concealed or under-floor ducting for

electrical cables and other services.

The design, plan and details of the site renovation/ modification

shall be vetted and approved prior to the award of the contract

and the quality shall be evaluated and accepted after the

completion of site renovation/ modification by the Electrical and

Mechanical Services Department (EMSD) and PWH.

In addition, the Tenderer shall ensure the site renovation/

modification is conducted by quality constructor and its Quality

and Standard shall fulfil the requirements stipulated in clause 3.

Any site renovation/ modification related to the proposed

SYSTEM shall be at no cost.

(M)

1.6 The proposed SYSTEM shall be ready for live run with

compliance to all requirements of stated in this tender

specifications within 6 months from the date of tender award.

(M)

1.7 The Tenderer shall provide application specialist support for the

method development for at least 5 years. The methods to be

developed shall include but not limited to plasma amino acid,

plasma renin activity, plasma/serum aldosterone, plasma/serum

estrogens, etc.

(M)

1.8 Except for the parameters of sample preparation, all other

parameters of the application methods shall be directly loaded

into the Control software and data processing unit depicted in

clause 2.2.4 without manual data entry.

(M)

1.9 The Tenderer shall provide all the currently available methods

and continuously update the method database for every newly

developed and validated method throughout the serviceable life

of the SYSTEM.

(M)

Section II - Technical Specifications

11

EOI Ref.: NTEC/P&MM/T5B/CBV2324-T003 EOI

Clause Description Type of

Clause

YES NO

(Provide

details)

M/D/O (Please tick as appropriate)

2.1 Ultra performance Liquid Chromatography Unit

2.1.1 Liquid chromatography - temperature controlled solvent

delivery module
2.1.1.1 The module shall use binary solvent delivery design. It shall be

able to accommodate four different solvents in two solvent

channels. The user shall be able to choose in each solvent

channel between two different solvents.

(M)

2.1.1.2 The module shall use single or dual pressure transducers or

functionally equivalent design for module performance

monitoring.

(M)

2.1.1.3 The module shall have automatic and continuous

compressibility compensation to ensure stable solvent delivery.

Functionally equivalent design is also acceptable.

(M)

2.1.1.4 The module shall have the capability for direct or indirect

bubble detection.

(M)

2.1.1.5 The module shall have the capability for automatic or manual

priming of module fluidic path.

(M)

2.1.1.6 The module shall have a vacuum degassing system with at least

six chambers and separate channels for each mobile solution

and wash solvents.

(M)

2.1.1.7 The module shall be equipped with controllable valves or

equivalent design to deliver fast module priming and start-up

times.

(M)

2.1.1.8 Flow rate shall be ranged from 10 l/min to 2 ml/min or wider

range, in 1 l/min increments or finer.

(M)

2.1.1.9 Flow precision shall be ≤ ±0.1% relative standard deviation

(RSD) and flow accuracy shall be ±1% or better.

(M)

2.1.1.10 Maximum operating pressure shall not be less than 18, 000psi at

a flow rate of 1 ml/min.

(M)

2.1.1.11 The module shall be able to run high performance liquid

chromatography (HPLC) columns with particle sizes ranged

from sub-2 m to 7.0 m or wider range, at flow rates above 0.5

ml/min without any hardware modifications.

(M)

2.1.1.12 The module shall automatically condition and blend up to 2

solvents for isocratic or gradient operation with composition

accuracy of ≤± 0.5% and composition precision of ≤± 0.2%

(relative SD based on retention time).

(M)

2.1.1.13 Total system dwell volume shall be less than 110 µL. (M)

12

EOI Ref.: NTEC/P&MM/T5B/CBV2324-T003 EOI

Clause Description Type of

Clause

YES NO

(Provide

details)

M/D/O (Please tick as appropriate)

2.1.2 Liquid chromatography - automated sample management

module
2.1.2.1 The module shall have random access capability to any sample

vial for multi-method operation.

(M)

2.1.2.2 The module shall accommodate sample containers on plate and

rack formats: 96- or 384-well microtiter plate, 2 or 4 ml vials on

rack or equivalent.

(M)

2.1.2.3 The module shall be able to simultaneously accommodate at

least 2 plates or 2 racks for the above sample containers.

(M)

2.1.2.4 The module shall have capability to detect the presence of

sample containers before injection.

(M)

2.1.2.5 The module shall have the capability for washing the sampling

needle with at least 2 different continuous fresh solvents from

independent solvent reservoirs.

(M)

2.1.2.6 Sample carryover shall be 0.003%. (m)

2.1.2.7 typical sample volume delivery precision shall be 0.3% rsd. (m)

2.1.2.8 injection volume shall be ranged from 1l to 1000 l or wider

range, with an extended injection volume option.

(m)

2.1.2.9 the temperature of the sample compartment shall be maintained

from 4 to 40 ºc or wider range, programmable in 1 ºc

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