Screen the A10 antibody for offtarget binding Tender - 133408517

Procurement Summary

Country: USA

Summary: Screen the A10 antibody for offtarget binding to plasma membrane proteins and secreted proteins

Deadline: 15 Jan 2026

Posting Date: 09 Jan 2026

Other Information

Notice Type: Tender

TOT Ref.No.: 133408517

Document Ref. No.:

Competition: ICB

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

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Tender Details

THIS IS A NOTICE OF INTENT TO AWARD A SOLE SOURCE ORDER AND NOT A REQUEST FOR QUOTATIONS.
This contract action is for the acquisition of services for which the Government intends to solicit and negotiate with only one source under the authority of Federal Acquisition Regulation (FAR) Subpart 13.106-1(b). The National Cancer Institute (NCI) intends to award a single source purchase order to Charles River Discovery Research Services UK Limited, Unit 3/4 High Peak Business Park, Buxton Road, Chinley, High Peak, SK23 6FJ, UK, for the acquisition of the screen of the A10 antibody for off-target binding to plasma membrane proteins and secreted proteins.
The National Cancer Institute (NCI) has a program to use an antibody called, 'A10' to target cancer cells that have a lot of the epidermal growth factor receptor on their cell surface. While this antibody has been extensively tested and characterized it is not known if it also binds any other cell surface proteins. The contractor shall perform an off-target screen on an NCI antibody and report back on any problematic interactions that could predict a serious side effect should the antibody be given to a cancer patient. The A10 is NOT known to bind other cell surface proteins or secreted proteins but this needs to be addressed in the off-target screen.
The anticipated period of performance will be 10-12 weeks after award.
The applicable North American Industry Classification System (NAICS) code for this acquisition is 541380 - Testing Laboratories and Services and a size standard of $19M.
NCI will solicit and negotiate directly with Charles River Discovery Research Services UK Limited and no solicitation will be issued. Interested parties may identify their interest and capability. Award is subject to approval of the Sole Source Justification. This notice of intent is not a request for competitive proposals or quotations; however, an interested party may submit a statement of capabilities if they believe they...
Department/Ind. Agency: health and human services, department of

Product Service Code: q301 - reference laboratory testing

NAICS Code: 541380 - Testing Laboratories and Services

Inactive Dates: jan 30, 2026

Inactive Policy: 15 days after response date

Documents

 Tender Notice