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Rrpv Bontnmj Tender in USA - 139833882

The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | ADMINISTRATION FOR STRATEGIC PREPAREDNESS AND RESPONSE has issued a Tender notice for the procurement of a Rrpv Bontnmj in the USA. This Tender notice was published on 20 Apr 2026 and is scheduled to close on 11 May 2026, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 139833882, while the tender notice number is SSN-BARDA-04202026 and Registering on the platform.

Procurement Summary

Country: USA

Summary: Rrpv Bontnmj

Deadline: 11 May 2026

Posting Date: 20 Apr 2026

Other Information

Notice Type: Tender

TOT Ref.No.: 139833882

Document Ref. No.: SSN-BARDA-04202026

Competition: ICB

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

Purchaser's Detail

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Tender Details

Botulinum neurotoxins (BoNT/A-G) inhibit acetylcholine release at the neuromuscular junction through cleavage of SNARE proteins (e.g., SNAP-25, VAMP, syntaxin). Currently, BoNT characterization, including toxin potency and neutralization by medical countermeasures, is measured using mouse-based bioassays, primarily the Mouse Potency Assay (MPA) and Mouse Neutralization Assay (MNA), respectively.
There is increasing scientific, ethical, and regulatory interest in transitioning to human-relevant in vitro systems that can provide mechanistic insight while reducing reliance on animal testing. NMJ micro-physiological systems may provide a biologically relevant platform capable of measuring BoNT potency and evaluating countermeasure efficacy.
BARDA is interested in understanding whether NMJ-based in vitro platforms could support future development of validated assays capable of reducing and potentially replacing reliance on mouse bioassays for BoNT potency and neutralization measurements, with specific interest in systems that can show recovery of neuronal signaling and thereby be appropriate for medical countermeasures evaluation.
Notice ID: ssn-barda-04202026

Department/Ind. Agency: health and human services, department of

Sub-tier: office of assistant secretary for preparedness and response

Office: barda - aspr / daappo / barda dcma

Product Service Code: 6505 - drugs and biologicals

NAICS Code: 541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Inactive Dates: may 26, 2026

Inactive Policy: 15 days after response date

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