Purchase of Service: Synthesis and Qualification Tender - 137781051

Procurement Summary

Country: France

Summary: Purchase of Service: Synthesis and Qualification of Long Non-Coding Mrna Sequences Interacting with P53

Deadline: 30 Mar 2026

Posting Date: 14 Mar 2026

Other Information

Notice Type: Tender

TOT Ref.No.: 137781051

Document Ref. No.: MAPA-Synthèse-ARNm-p53

Competition: ICB

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

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Tender Details

The desired service The maternally expressed gene 3 (MEG3) encodes an lncRNA (long non-coding RNA) with a tumor suppressor effect which modulates the responses of the p53 protein. The structure of this lncRNA contains two distal motifs conserved during of evolution which interact by complementarity of bases to form mutually exclusive pseudo-knot structures (see figure). Mutations that disrupt these interactions have been shown to impair MEG3-dependent stimulation of p53 in vivo and disrupt MEG3 folding in vitro [1]. The required service consists of the production of synthetic lncRNA sequences in biologically active conformations that recapitulate MEG3 pseudoknot structures under a chemical form allowing their encapsulation into controllable liposomal carriers for delivery into cancer cell organoids and murine xenografts. Mutant forms (disrupted interactions) will also be produced to be used as a negative control. The production protocol will integrate non-denaturing purification of lncRNAs with in-solution hydrodynamic analysis and atomic force microscopy (AFM) imaging to produce lncRNA preparations. highly homogeneous, controlled by the visualization of their 3D topology at a resolution of approximately 15 Å [2]
Lot(s): Table of information on the different lots of the notice in 3 columns: Lot number, Title and Submission deadline. Lot number Title Offer selection criteria 1 Purchase of service: Synthesis and qualification of mRNA sequences long coding cells interacting with p53 Type of procedure: Procedure adapted to an envelope Deadline for submission of envelopes: March 30, 2026 12:00 p.m. (Paris time)

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