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Professional services for Fumarate Toxicology Tender, United Kingdom - 24972077

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE has floated a tender for Professional services for Fumarate Toxicology. The project location is United Kingdom and the tender is closing on 01 Aug 2018. The tender notice number is JUL259066, while the TOT Ref Number is 24972077. Bidders can have further information about the Tender and can request the complete Tender document by Registering on the site.

Procurement Summary

Country : United Kingdom

Summary : Professional services for Fumarate Toxicology

Deadline : 01 Aug 2018

Other Information

Notice Type : Tender

TOT Ref.No.: 24972077

Document Ref. No. : JUL259066

Competition : ICB

Financier : Self Financed

Purchaser Ownership : -

Tender Value : Refer Document

Purchaser's Detail

Purchaser : THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
The Chancellor, Masters and Scholars of the University of Cambridge
Procurement Services, 1st Floor South, Greenwich House, Madingley Rise
Cambridge
CB3 0TX
UK
Contact person : Tom Twitchett
E-mail : purchasing.intend@admin.cam.ac.uk
NUTS : UKH12
Internet address(es)
Main address : www.in-tendhost.co.uk/universityofcambridge

United Kingdom
Email :purchasing.intend@admin.cam.ac.uk
URL :www.in-tendhost.co.uk/universityofcambridge

Tender Details

The Department of Radiology of the University of Cambridge strive to be an internationally competitive department undertaking innovative research in medical imaging. We have a team of dedicated academic radiologists working with imaging scientists with an active doctoral and post-doctoral research programme. We have extensive facilities across Addenbrooke s Hospital, including one 3T MRI, five 1.5T MRI machines, PET CT and four CT machines on which we undertake research. There is a large ultrasound department and a nuclear medicine facility. We are part of the Wolfson Brain Imaging Centre (WBI...

Title: Professional services for Fumarate Toxicology

Published by: The Chancellor, Masters and Scholars of the University of Cambridge

Publication Date: 12/07/2018

Deadline Date: 01/08/2018

Deadline Time: 11:59

Notice Type: Contract Notice

Has Documents: No

Has ESPD: No

Abstract: We are developing fumarate as a new agent to use in Radiology to perform metabolism imaging. We are currently using pyruvate in physiological human studies for metabolism imaging and are looking at progressing fumarate to first-in-man studies.Magnetic resonance spectroscopy (MRS) is capable of non-invasive imaging of biochemical reactions in vivo by allowing both substrates and products to be detected. However, its lack of sensitivity and relatively low temporal resolution results in images that, at best, can only be produced at relatively low spatial resolution and generally prevents real-time imaging in humans, producing only a static picture of tissue metabolism.Introduction of a 13C-labelled substrate (13C is a stable, non-radioactive form of carbon, which is MR-active) and detection of the 13C-labelled metabolites formed from it using 13C-MRS, can provide information on metabolic flux. As 13C-MRS is significantly less sensitive than proton (1H) MRS, the introduction of dissolution DNP, where hyperpolarization of the 13C nucleus enhances its sensitivity to detection by more than 10 000-fold, has allowed dynamic imaging of cellular metabolic fluxes in vivo i...