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The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH has issued a Tender notice for the procurement of a Niddk in Vivo Efficacy of Fcbispecifics Study in the USA. This Tender notice was published on 29 Jul 2026 and is scheduled to close on 06 Aug 2026, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 146112627, while the tender notice number is 75N98026Q00898TACONICBIOSCIENCESINC and Registering on the platform.
Procurement Summary
Country: USA
Summary: Niddk in Vivo Efficacy of Fcbispecifics Study
Deadline: 06 Aug 2026
Posting Date: 29 Jul 2026
Other Information
Notice Type: Tender
TOT Ref.No.: 146112627
Document Ref. No.: 75N98026Q00898TACONICBIOSCIENCESINC
Competition: ICB
Financier: Self Financed
Purchaser Ownership: Public
Tender Value: Refer Document
Purchaser's Detail
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Address: Login to see tender_details
Email: Login to see tender_detailsLogin to see details Tender Details As part of the statutorily required functions of the National Institute of Health (NIH), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports a wide range of biomedical research directly through intramural research within NIH laboratories, and externally through grants to universities and other medical research institutions across the country. In addition, NIDDK supports research training for students and scientists at various stages of their careers and a range of education and outreach programs to bring science-based information to patients and their families, health care professionals, and the public. Documents
Within the Laboratory of Bioorganic Chemistry, NIDDK, the Natural Products Chemistry Section (NPCS) requires studies to determine the in vivo anti- human immunodeficiency virus (HIV) and immune-recruiting activity of a novel panel of antibody or Fc-lectin/nanobody conjugates (termed antibody-protein conjugates or APC-s). These studies are being performed with optimized APCs that have been shown to prevent HIV infection in cell-based and vivo studies. The research study is needed to expand a recent pilot study in humanized CD34+ mice (strain NOD- Prkdcem26Cd52Il2rgem26Cd22 /NjuCrl). The protocols used will measure antiviral efficacy of the APCs in both pre-infection and post-infection studies. Viral infection will be measured by polymerase chain reaction (PCR) and flow cytometry of T-cells in infected and control mice. In-life blood collections will be conducted on study dates every 2 weeks (W#): -1 day (W0), W2, W4, S6 and W8 (end-point) or +1 day (W0), W2, W4, S6 and W8 (end-point). A terminal blood collection will be conducted on day 56 for all mice. Blood processing and serum preparations will be conducted on all samples. Additionally, PCR and flow cytometry will be conducted. A total of six study groups comprising six CD34+ mice per group will be used for testing of five APCs plus vehicle control.
The NPCS carr...
Notice ID: 75n98026q00898taconicbiosciencesinc
Department/Ind. Agency: health and human services, department of
Sub-tier: national institutes of health
Office: national institutes of health olao
Product Service Code: 6640 - laboratory equipment and supplies
NAICS Code: 112990 - All Other Animal Production
Inactive Dates: aug 07, 2026
Inactive Policy: manual
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