Nanobody Affinity Maturation using Phage Display Selection Tender, USA - 123058406

Procurement Summary

Country: USA

Summary: Nanobody Affinity Maturation using Phage Display Selection

Deadline: 01 Aug 2025

Other Information

Notice Type: Tender

TOT Ref.No.: 123058406

Document Ref. No.: 75N91025Q00049

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

Purchaser's Detail

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Tender Details

Description

The National Cancer Institute (NCI)-s Center for Cancer Research Office (CCR) Molecular Imaging Branch (MIB) plans to procure on a sole source basis services for targeted affinity maturation of an anti-human BCMA nanobody via phage display library construction and selection. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) via request for written quotation.Only one (1) award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The Period of Performance is estimated to be a base period of six (6) months from the effective date stated in the award.

2.0 BACKGROUNDThe National Cancer Institute/Center for Cancer Research (NCI/CCR), Molecular Imaging Branch (MIB) is engaged in the development of radiolabeled nanobodies targeting clinically relevant tumor antigens for diagnostic and therapeutic applications. One of the current programs focuses on targeting B-cell maturation antigen (BCMA) in multiple myeloma. A parental anti-human BCMA nanobody was purchased and demonstrated promising preliminary binding in vitro and in vivo, but further affinity enhancement is required to support translational applications. The goal is to generate high affinity nanobody variants (based on the parental one), suitable for imaging and radiotherapy through affinity maturation using phage display.

3.0 OBJECTIVEThe Contractor shall perform targeted affinity maturation of an anti-human BCMA nanobody via phage display library construction and selection. The objective is to deliver five affinity-optimized nanobody sequences along with sufficient purified protein for in vitro and in vivo testing.

4.0 SCOPEThe Contractor shall perform nanobody affinity maturation using established phage display techniques. The project will be based on nanobody sequence provided by the Government and will encompass a series of integrated activities aimed at enhanc...
Active Contract Opportunity
Notice ID : 75N91025Q00049
Related Notice
Department/Ind. Agency : HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier : NATIONAL INSTITUTES OF HEALTH
Office: NIH NCI
General Information
Contract Opportunity Type: Presolicitation (Original)
Original Published Date: Jul 18, 2025 02:42 pm EDT
Original Response Date: Aug 01, 2025 03:00 pm EDT
Inactive Policy: 15 days after response date
Original Inactive Date: Aug 16, 2025
Initiative: None

Classification
Original Set Aside:
Product Service Code: Q301 - REFERENCE LABORATORY TESTING
NAICS Code: 541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance: Rockville, MD USA

Documents

 Tender Notice

Att-1-Nanobody-Affinity-Maturation-SOW-071825.pdf