Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk... Tender

Procurement Summary

Country: USA

Summary: Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk of Carcinogenesis in an Outbred Mouse Model (HS/Npt)

Deadline: 18 Sep 2025

Other Information

Notice Type: Tender

TOT Ref.No.: 126160815

Document Ref. No.: 80JSC025IRM001

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

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Tender Details

Description

1. Background

Astronauts on long-duration space missions are exposed to galactic cosmic rays (GCR) and solar particle events (SPE), creating elevated risks of carcinogenesis, cardiovascular disease (CVD), and central nervous system (CNS) decrements. Traditional inbred animal models have limitations due to genetic uniformity, potentially leading to overestimation of relative biological effectiveness (RBE). Outbred mouse models (HS/Npt) provide a genetically diverse system that better mirrors human populations and may yield more accurate assessments of radiation-induced cancer and related health risks.

2. Objectives

The objectives of this study are to:1. Determine the effects of radiation quality, dose, and dose rate on cancer initiation, promotion, and progression in HS/Npt outbred mice.2. Establish RBEs and quality factor estimates for space-relevant radiation exposures.3. Provide biobanked tissue and comprehensive metadata to support future NASA investigations.4. (Optional) Assess cardiovascular and CNS outcomes, as well as sex-specific responses, within budget constraints.

3. Scope of Work

The Principal Investigator (PI) shall design and execute experiments utilizing outbred HS/Npt mice supplied by NASA. Work shall include:- Radiation exposures at technically acceptable laboratory (See attached laboratory technical acceptability requirements sheet), including gamma irradiation, full GCR simulation (acute and fractionated), and single-ion exposures (e.g., 56Fe) where justified.- Dose coverage relevant to Mars design reference missions (300-450 mGy).- Survival, tumor incidence, and tumor spectrum analyses.- Comprehensive tissue collection, preservation, and metadata management.- Biobanking of required samples per NASA specifications.- Preparation of interim and final reports.

This is stricly a request for information. The Government has no obligation for award. If interested please provide a capabilities statement.
Active Contract Opportunity
Notice ID : 80JSC025IRM001
Related Notice
Department/Ind. Agency : NATIONAL AERONAUTICS AND SPACE ADMINISTRATION
Sub-tier : NATIONAL AERONAUTICS AND SPACE ADMINISTRATION
Office: NASA JOHNSON SPACE CENTER
General Information
Contract Opportunity Type: Sources Sought (Original)
Original Published Date: Sep 11, 2025 09:24 am CDT
Original Response Date: Sep 18, 2025 01:00 pm CDT
Inactive Policy: 15 days after response date
Original Inactive Date: Oct 03, 2025
Initiative: None

Classification
Original Set Aside:
Product Service Code:
NAICS Code: 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance: Houston, Tx USA

Documents

 Tender Notice

GCR-Sim-Table-1.pdf