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The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH has issued a Tender notice for the procurement of a Dovetail Genomics Llc Microc Service in the USA. This Tender notice was published on 17 Jul 2026 and is scheduled to close on 25 Jul 2026, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 145330894, while the tender notice number is 75N98026Q00789 and Registering on the platform.
Procurement Summary
Country: USA
Summary: Dovetail Genomics Llc Microc Service
Deadline: 25 Jul 2026
Posting Date: 17 Jul 2026
Other Information
Notice Type: Tender
TOT Ref.No.: 145330894
Document Ref. No.: 75N98026Q00789
Competition: ICB
Financier: Self Financed
Purchaser Ownership: Public
Tender Value: Refer Document
Purchaser's Detail
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Login to see detailsTender Details
Requirements:
1. Purpose
Dovetail Genomics LLC Micro-C service employs micrococcal nuclease (MNase) digestion to generate highly uniform fragments, enabling precise capture of nucleosome positioning with even genomic coverage. This approach provides increased mapping resolution at the nucleosome level, while proximity ligation data enriched for long-range informative reads allows detection of higher-order chromatin organization, including chromatin loops and interaction frequencies. The purpose of this Statement of Work is to acquire Dovetail Genomics LLC Micro-C services for samples processing and associated data generation in support of NCI/CCR/LRBGE research on the effects of substrate stiffness on 3D chromatin architecture in colon cancer cell lines. This information will allow us to better understand the impact of substrate stiffness on gene regulation and cancer cell behavior.
2. Background
Mechanical cues regulate cell behavior in development, regeneration, aging, and disease, and in colon cancer, extracellular matrix stiffening may promote malignancy by altering focal adhesions, YAP1 transcription factor activity, invasion, transcriptional programs, and nuclear organization. Given the rising incidence of colorectal cancer in young adults and the NIH emphasis on human-based, animal-free research models, we will compare human colon cancer cells grown on substrates of different stiffnesses to determine whether physiologically relevant soft hydrogels, compared with rigid plastic, alter 3D nuclear architecture assessed by Micro-C. This work will test whether matrix stiffness reshapes chromatin organization and mechanosensitive transcriptional responses in ways that may be missed in conventional culture, supporting more predictive human-based models for cancer biology research.
Although third-party service contractors may theoretically offer related sample-processing support, they would not provide the same Dovetail Genomics LLC quality micro-C ...
Notice ID: 75n98026q00789
Department/Ind. Agency: health and human services, department of
Original Set Aside: total small business set-aside (far 19.5)
Sub-tier: national institutes of health
Office: national institutes of health olao
Product Service Code: 6505 - drugs and biologicals
NAICS Code: 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
Inactive Dates: jul 25, 2026
Inactive Policy: manual
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