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Development of a Risk of Bias Tool Tender in Canada - 144241374

The CANADA-S DRUG AGENCY has issued a Tender notice for the procurement of a Development of a Risk of Bias Tool for Population-Adjusted Indirect Comparisons in the Canada. This Tender notice was published on 30 Jun 2026 and is scheduled to close on 22 Jul 2026, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 144241374, while the tender notice number is C-262701520 and Registering on the platform.

Procurement Summary

Country: Canada

Summary: Development of a Risk of Bias Tool for Population-Adjusted Indirect Comparisons

Deadline: 22 Jul 2026

Posting Date: 30 Jun 2026

Other Information

Notice Type: Tender

TOT Ref.No.: 144241374

Document Ref. No.: C-262701520

Competition: ICB

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

Purchaser's Detail

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Tender Details

Indirect treatment comparisons (ITCs) play a critical role in informing decision-making within health technology assessments (HTAs), particularly when direct head-to-head evidence is unavailable. Drug sponsors commonly submit a range of ITC methodologies, including network meta-analyses (NMAs) and population-adjusted indirect comparisons (PAICs). PAIC methods such as matching-adjusted indirect comparisons (MAICs), simulated treatment comparisons (STCs), and multilevel network meta-regression (ML-NMR) are increasingly used to compare new therapies with relevant comparators.However, their validity depends on methodological choices, data availability, and assumptions that can introduce substantial bias and uncertainty. CDA-AMC seeks to engage an external vendor with expertise in evidence synthesis, indirect treatment comparisons, and methodological tool development to design a comprehensive, practical, and reproducible Risk of Bias Tool for PAICs. For more information, see the RFP Main Document.
Solicitation Type : RFP - Request for Proposal (Formal) Reference Number : 0000325932 Location : Canada, All of Canada, All of Canada Delivery Point : [email protected] Description : Indirect treatment comparisons (ITCs) play a critical role in informing decision-making within health technology assessments (HTAs), particularly when direct head-to-head evidence is unavailable. Drug sponsors commonly submit a range of ITC methodologies, including network meta-analyses (NMAs) and population-adjusted indirect comparisons (PAICs). PAIC methods such as matching-adjusted indirect comparisons (MAICs), simulated treatment comparisons (STCs), and multilevel network meta-regression (ML-NMR) are increasingly used to compare new therapies with relevant comparators.However, their validity depends on methodological choices, data availability, and assumptions that can introduce substantial bias and uncertainty. CDA-AMC seeks to engage an external vendor with expertise in evidence synthesis, indirect treatment comparisons, and methodological tool development to design a comprehensive, practical, and reproducible Risk of Bias Tool for PAICs. For more information, see the RFP Main Document.

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