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The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH has issued a Tender notice for the procurement of a Development and Validation of an Antibody for Detection of Lysine Homocysteinylation in Cobalamin Disorders in the USA. This Tender notice was published on 04 Jun 2026 and is scheduled to close on 13 Jun 2026, with an estimated Tender value of Refer Document. Interested bidders can access detailed Tender information, eligibility criteria, and complete bidding documents by referencing TOT Ref No. 142595567, while the tender notice number is 75N98026Q00506 and Registering on the platform.
Procurement Summary
Country: USA
Summary: Development and Validation of an Antibody for Detection of Lysine Homocysteinylation in Cobalamin Disorders
Deadline: 13 Jun 2026
Posting Date: 04 Jun 2026
Other Information
Notice Type: Tender
TOT Ref.No.: 142595567
Document Ref. No.: 75N98026Q00506
Competition: ICB
Financier: Self Financed
Purchaser Ownership: Public
Tender Value: Refer Document
Purchaser's Detail
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Email: Login to see tender_detailsLogin to see details Tender Details Requirements: Documents
The proposed development of a novel post-translational modification (PTM)-specific antibody directly supports the U.S. Government's mission to advance biomedical research on rare genetic diseases, improve public health outcomes, and accelerate the development of precision medicine approaches
Currently there is no commercially available antibody against N-homocysteine-lysine (N-homocysteinylation) so we will need to have one generated. By generating it, we are able to provide specifications for the peptide sequence based on preliminary findings in our scientific models of disease insuring it will work effectively. Our objectives are as follows:
Synthesize and purify peptide antigens with N-homocysteinylated lysine residues and matched control peptides with unmodified lysines. Conjugate peptides to carrier proteins (e.g., KLH) for immunization
Immunize appropriate host species (rabbit for polyclonal antibody generation)
Generate polyclonal sera prior to immunization and 2 to 3 times after following antigen boost. Test sera on lab samples of N-homocysteinylated proteins from mouse models of MMACHC delicacy in our lab. Also perform ELISA screening of antibody on modified and unmodified peptide.
Terminal bleed on immunized animal and purification of working antibody from serum
With working antibody we will characterize the proteins affected by this aberrant posttranslational modification to better understand disease development and in future design targeted therapies for it.
Notice ID: 75n98026q00506
Department/Ind. Agency: health and human services, department of
Original Set Aside: total small business set-aside (far 19.5)
Sub-tier: national institutes of health
Office: national institutes of health olao
Product Service Code: q301 - reference laboratory testing
NAICS Code: 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
Inactive Dates: jun 14, 2026
Inactive Policy: manual
Procurement Documents for USA
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