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HEALTH AND HUMAN SERVICES, DEPARTMENT OF has floated a tender for Comprehensive Toxicity Analysis of Individual Ends. The project location is USA and the tender is closing on 11 Aug 2023. The tender notice number is FDA-RFP-75F40123R00115, while the TOT Ref Number is 86774765. Bidders can have further information about the Tender and can request the complete Tender document by Registering on the site.
Procurement Summary
Country : USA
Summary : Comprehensive Toxicity Analysis of Individual Ends
Deadline : 11 Aug 2023
Other Information
Notice Type : Tender
TOT Ref.No.: 86774765
Document Ref. No. : FDA-RFP-75F40123R00115
Financier : Self Financed
Purchaser Ownership : Public
Tender Value : Refer Document
Purchaser's Detail
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Login to see detailsTender Details
Description
The Contractor shall investigate the toxicity of 125 flavor ingredient chemicals alone and combined with metal using high throughput assays. The FDA will produce a final library of 125 flavor ingredient chemicals based on the predicted propensity of flavor ingredient chemicals to interact with metals. The Contractor shall perform cytotoxicity assays and measurements of cytokine levels in the supernatant to determine appropriate sublethal concentrations of flavor ingredient chemicals and metals to use in subsequent mutagenic and genotoxic assays, which consist of assays in cells lines and in bacteria. The Contractor shall determine based on measurables of the mutagenic and genotoxic experiments a list of 20 flavor ingredient chemicals and 20 flavor-metal combinations and their concentrations to be tested in the reconstructed human lung tissue model to measure the effects on metabolism, membrane integrity, cell viability, inflammation, and DNA damage. The Contractor shall perform all data analyses, provide FDA all of the raw data, and write study reports.
Active Contract Opportunity
Notice ID : FDA-RFP-75F40123R00115
Related Notice
Department/Ind. Agency : HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier : FOOD AND DRUG ADMINISTRATION
Office : FDA OFFICE OF ACQ GRANT SVCS
General Information
Contract Opportunity Type: Combined Synopsis/Solicitation (Updated)
All Dates/Times are: (UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA
Updated Published Date: Aug 04, 2023 12:44 pm EDT
Original Published Date: Jul 20, 2023 01:24 pm EDT
Updated Date Offers Due: Aug 11, 2023 03:00 am EDT
Original Date Offers Due: Aug 04, 2023 01:00 pm EDT
Inactive Policy: 15 days after date offers due
Updated Inactive Date: Aug 26, 2023
Original Inactive Date: Aug 19, 2023
Initiative: None
Classification
Original Set Aside:
Product Service Code: AN31 - Health R&D Services; Consumer and occupational health and safety; Basic Research
NAICS Code: 541690 - Other Scientific and Technical Consulting Services
Place of Performance: USA
Documents
Final-solicitation_Comprehensive-toxicity-analysis-of-individual-ENDS-.pdf
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