Autoantibody Profiles and Polyautoimmunity in Aging Tender, USA - 125274491

Procurement Summary

Country: USA

Summary: Autoantibody Profiles and Polyautoimmunity in Aging

Deadline: 03 Sep 2025

Other Information

Notice Type: Tender

TOT Ref.No.: 125274491

Document Ref. No.: 75N95025Q05864

Financier: Self Financed

Purchaser Ownership: Public

Tender Value: Refer Document

Purchaser's Detail

Name: Login to see tender_details

Address: Login to see tender_details

Email: Login to see tender_details

Login to see details

Tender Details

Description

Autoimmune diseases are a leading cause of chronic illness and disability, particularly among women and older adults. Many individuals develop more than one autoimmune condition, a phenomenon known as polyautoimmunity. Polyautoimmunity is associated with greater disease burden, more complex treatment needs, and heightened immune dysregulation. Despite its importance, it remains poorly understood, especially in aging populations.

This project will evaluate whether older adults with polyautoimmunity demonstrate unique or intensified autoantibody patterns, and whether specific immune signatures are linked to aging outcomes such as frailty and multimorbidity. The BLSA, with its deeply phenotyped cohort and biobanked serum samples, provides an ideal setting for this work.

The contractor shall construct and perform antibody array testing using a high-throughput immunoproteomics approach for

1, 700 proteins targeting selected autoantigens in 270 blood samples. The contractor must construct and perform antibody assays for tens of thousands of antigens in hundreds of samples AND for hundreds of antigens in tens of thousands of samples. The contractor should support data analysis and interpretation. The contractor needs to be proficient in high-throughput multiplex assays for disease-associated antibodies, as demonstrated by peer-reviewed publications, meeting presentations, and/or other scientific reports.

Specific requirements for the assay platforms are as follows.

Well-folded and often functional protein antigens, including conformational epitopes Use of freshly produced full-length antigens Easy data interpretation of target antigens of disease-associated antibodies Flexible and expedient adjustment of antigen contents Flexible with producing antigens using different expression systems Capable of assaying both human and microbial antigens simultaneously High-yield protein features with high sensitivity Quantitatively reproducible Comp...
Active Contract Opportunity
Notice ID : 75N95025Q05864
Related Notice
Department/Ind. Agency : HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier : NATIONAL INSTITUTES OF HEALTH
Office: NATIONAL INSTITUTES OF HEALTH NIDA
General Information
Contract Opportunity Type: Sources Sought (Original)
Original Published Date: Aug 27, 2025 11:29 am EDT
Original Response Date: Sep 03, 2025 02:00 pm EDT
Inactive Policy: 15 days after response date
Original Inactive Date: Sep 18, 2025
Initiative: None

Classification
Original Set Aside:
Product Service Code: B504 - SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL
NAICS Code: 621511 - Medical Laboratories

Place of Performance: Baltimore, MD USA

Documents

 Tender Notice